Identical mutations of the p53 tumor suppressor gene in the gliomatous and the sarcomatous components of gliosarcomas suggest a common origin from glial cells

Details

Serval ID
serval:BIB_53DC64926056
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Identical mutations of the p53 tumor suppressor gene in the gliomatous and the sarcomatous components of gliosarcomas suggest a common origin from glial cells
Journal
Journal of Neuropathology and Experimental Neurology
Author(s)
Biernat  W., Aguzzi  A., Sure  U., Grant  J. W., Kleihues  P., Hegi  M. E.
ISSN
0022-3069 (Print)
Publication state
Published
Issued date
09/1995
Volume
54
Number
5
Pages
651-6
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Sep
Abstract
Gliosarcomas are morphologically heterogeneous tumors of the central nervous system composed of gliomatous and sarcomatous components. The histogenesis of the latter is still a matter of debate. As mutations of the p53 tumor suppressor gene represent an early event in the development of gliomas, we attempted to determine whether both components of gliosarcomas share identical alterations of the p53 gene. Using single-strand conformation analysis (SSCA) and direct DNA sequencing of the p53 gene, we analyzed dissected gliomatous and sarcomatous parts of 12 formalin-fixed, paraffin-embedded gliosarcomas. The two tumors that contained a p53 alteration were found to carry the identical mutation (exon 5; codon 151, CCC-->TCC; codon 173, GTG-->GTA) in the gliomatous and the sarcomatous components. These findings suggest a common origin of the two cellular components from neoplastic glial cells.
Keywords
Adult Aged Base Sequence Brain Neoplasms/*genetics/pathology Central Nervous System Neoplasms/*genetics/pathology Child Codon Exons Female *Genes, p53 Glioma/genetics/pathology Gliosarcoma/*genetics/pathology Humans Male Middle Aged Neuroglia/cytology/*pathology *Point Mutation Polymerase Chain Reaction Polymorphism, Genetic Sarcoma/genetics/pathology
Pubmed
Web of science
Create date
25/01/2008 13:05
Last modification date
20/08/2019 14:08
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