A case of acute dapsone poisoning: toxicological data and review of the literature.
Details
Serval ID
serval:BIB_53D1D6D37172
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
A case of acute dapsone poisoning: toxicological data and review of the literature.
Journal
Journal of Analytical Toxicology
ISSN
0146-4760[print], 0146-4760[linking]
Publication state
Published
Issued date
1995
Volume
19
Number
4
Pages
229-235
Language
english
Abstract
A case of nonfatal, acute poisoning following the ingestion of an undetermined amount of dapsone (DDS) in a 49-year-old woman is presented. The clinical features were dyspnea and deep cyanosis. Methemoglobinemia was 39.0% on admission. DDS was identified and quantitated in blood samples taken on the third day (sample A) and fifth day (sample B) in the hospital using a high-performance liquid chromatographic technique with diode-array detection. DDS concentrations were 26.99 and 8.40 micrograms/mL in samples A and B, respectively. Results are discussed in the light of an extensive review of the literature (1950-1993) available on DDS poisonings.
Keywords
Chromatography, High Pressure Liquid, Cyanosis/chemically induced, Dapsone/blood, Dapsone/poisoning, Dyspnea/chemically induced, Female, Humans, Leprostatic Agents/blood, Leprostatic Agents/poisoning, Middle Aged
Pubmed
Create date
19/10/2010 16:37
Last modification date
20/08/2019 15:08
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