Reduction of plasma alanine aminotransferase during vigabatrin treatment.
Details
Serval ID
serval:BIB_53B494698A8B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Reduction of plasma alanine aminotransferase during vigabatrin treatment.
Journal
Epilepsia
ISSN
0013-9580 (Print)
ISSN-L
0013-9580
Publication state
Published
Issued date
1995
Volume
36
Number
8
Pages
804-809
Language
english
Abstract
In 9 drug-resistant patients with partial seizures treated with vigabatrin, gamma-vinyl GABA (VGB), alanine aminotransaminase (ALAT) activity in plasma was significantly reduced. Comparison of in vitro with in vivo measurements led us to conclude that this reduction is mainly an in vivo phenomenon, perhaps due to cross-enzyme inhibition. The assessment of two biological variables linked with ALAT, glucose and alanine levels under fasting conditions, failed to show any significant metabolic alterations. VGB is an effective drug for partial epilepsy. Our observations do not suggest that reduced ALAT activity is of clinical concern.
Keywords
Adolescent, Adult, Alanine/blood, Alanine Transaminase/blood, Anticonvulsants/blood, Anticonvulsants/therapeutic use, Blood Glucose/analysis, Epilepsies, Partial/blood, Epilepsies, Partial/drug therapy, Fasting, Female, Humans, Male, Middle Aged, Prospective Studies, Vigabatrin, gamma-Aminobutyric Acid/analogs & derivatives, gamma-Aminobutyric Acid/blood
Pubmed
Web of science
Create date
02/09/2011 19:55
Last modification date
20/08/2019 15:08
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