Imatinib plasma concentrations variability in oncologic patients

Détails

ID Serval
serval:BIB_5376CBEA44B3
Type
Livre: un livre et son éditeur.
Collection
Publications
Titre
Imatinib plasma concentrations variability in oncologic patients
Auteur(s)
Widmer N.
Editeur
LAP Lambert Academic Publishing
Lieu d'édition
Saarbrücken, Germany
ISBN
9783838385112
Statut éditorial
Publié
Date de publication
2010
Langue
anglais
Nombre de pages
248 p.
Résumé
The anticancer drug imatinib has transformed the treatment and prognosis of chronic myeloid leukemia and gastrointestinal stromal tumor. However, the treatment must be taken indefinitely and is not devoid of inconveniences and toxicity. Moreover, resistance or escape from disease control are occurring. Considering the large interindividual differences in the function of the enzymatic and transport systems involved in imatinib disposition, exposure to this drug can be expected to vary widely among patients. This book describes an observational clinical trial aiming at exploring the influence of these covariates on imatinib pharmacokinetics and assessing the interindividual variability of the pharmacokinetic parameters of the drug. A large interindividual variability was observed, together with some preliminary concentration-effect relationships. These elements are arguments to further investigate the potential benefit of a therapeutic drug monitoring program to optimize the use of imatinib in patients. Such results should be especially useful to clinical oncologists or scientists involved in clinical oncology research.
Création de la notice
07/12/2010 15:48
Dernière modification de la notice
20/08/2019 14:08
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