Radiolabeling of monoclonal antibody against carcinoembryonic antigen with 88Y and biodistribution studies.

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Serval ID
serval:BIB_536D4A4DFBC3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
UNIL/CHUV
Title
Radiolabeling of monoclonal antibody against carcinoembryonic antigen with 88Y and biodistribution studies.
Journal
International Journal of Nuclear Medicine and Biology
Author(s)
Buchsbaum D.J., Hanna D.E., Randall B.C., Buchegger F., Mach J.P.
ISSN
0969-8051
0047-0740 (Print)
ISSN-L
0047-0740
Publication state
Published
Issued date
1985
Volume
12
Number
2
Pages
79-82
Language
english
Abstract
The biodistribution of the 202 monoclonal antibody against CEA labeled with 88Y by the bicyclic DTPA anhydride method was studied in normal Balb/c mice. The in vitro binding to 1 X 10(7) CO112, LS174T and WiDR colon cancer cells was 21.0, 27.3 and 18.8%, respectively. The binding to an equal number of KM-3 leukemia cells and normal human lymphocytes was 8.9 and 3.2%, respectively. Liver, spleen, kidney and blood were the tissues that showed the highest uptake of radiolabeled antibody in vivo.
Keywords
Animals, Antibodies, Monoclonal, Carcinoembryonic Antigen/analysis, Carcinoembryonic Antigen/immunology, Cell Line, Colonic Neoplasms, Epitopes/analysis, Immunoassay, Kinetics, Leukemia, Mice, Mice, Inbred BALB C, Tissue Distribution, Yttrium Radioisotopes/diagnostic use
OAI-PMH
oai:serval.unil.ch:BIB_536D4A4DFBC3
DOI
10.1016/0047-0740(85)90160-3
Pubmed
2412985
Web of science
A1985AMU2300001
Create date
25/01/2008 11:27
Last modification date
20/08/2019 14:08
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