A retrospective study of 150 patients with lentigo maligna and lentigo maligna melanoma and the efficacy of radiotherapy using Grenz or soft X-rays

Détails

ID Serval
serval:BIB_5367211FC950
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
A retrospective study of 150 patients with lentigo maligna and lentigo maligna melanoma and the efficacy of radiotherapy using Grenz or soft X-rays
Périodique
British Journal of Dermatology
Auteur(s)
Farshad  A., Burg  G., Panizzon  R., Dummer  R.
ISSN
0007-0963 (Print)
Statut éditorial
Publié
Date de publication
06/2002
Volume
146
Numéro
6
Pages
1042-6
Notes
Journal Article --- Old month value: Jun
Résumé
BACKGROUND: Lentigo maligna (LM) and lentigo maligna melanoma (LMM) are the most common melanocytic neoplasms on sun-exposed skin of elderly patients. OBJECTIVES: To perform a retrospective study of 150 patients with LM and LMM treated with radiotherapy using Grenz or soft X-rays. METHODS: The information recorded and analysed included gender, age, diagnosis, size of the lesion, localization, X-ray treatment, recurrence rate, other skin malignancies and non-dermatological neoplasms. RESULTS: The 150 patients comprised 78 women and 72 men (mean age 70 years). Ninety-three patients had LM, 54 had LMM and three had both neoplasms. Ninety per cent of lesions were located on the face. Treatment was with Grenz rays in 96 patients with LM and 11 with LMM (70%) and with soft X-rays in 46 patients with LMM (30%). Three patients were treated using both modalities. One hundred and one patients were followed up for at least 2 years after radiotherapy (mean 8 years). The mean time to recurrence was 45.6 months, and the recurrence rate was 7% (seven of 101). Other skin malignancies were observed in 65 of 150 patients, including basal cell carcinoma in 23 (35%) and actinic keratosis in 20 (31%). Four patients developed internal cancers. CONCLUSIONS: The study showed that radiotherapy of LM and LMM was curative. In particular, radiotherapy proved to be an excellent treatment for elderly patients. Owing to the high incidence of other skin cancers, LM patients need careful follow-up.
Mots-clé
Adult Age Distribution Aged Aged, 80 and over Female Follow-Up Studies Humans Hutchinson's Melanotic Freckle/pathology/*radiotherapy Male Middle Aged Retrospective Studies Skin Neoplasms/pathology/*radiotherapy Treatment Outcome
Pubmed
Web of science
Création de la notice
25/01/2008 16:54
Dernière modification de la notice
20/08/2019 14:08
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