Prognosis of cardiovascular and non-cardiovascular multimorbidity after acute coronary syndrome.

Détails

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Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_535BD91177FC
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Prognosis of cardiovascular and non-cardiovascular multimorbidity after acute coronary syndrome.
Périodique
PloS one
Auteur(s)
Canivell S., Muller O., Gencer B., Heg D., Klingenberg R., Räber L., Carballo D., Matter C., Lüscher T., Windecker S., Mach F., Rodondi N., Nanchen D.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Statut éditorial
Publié
Date de publication
2018
Peer-reviewed
Oui
Volume
13
Numéro
4
Pages
e0195174
Langue
anglais
Notes
Publication types: Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Résumé
To examine the prognosis of patients with cardiovascular and non-cardiovascular multimorbidity after acute coronary syndrome compared to patients without prior multimorbidity.
This multicenter prospective cohort study in Switzerland included 5,635 patients hospitalized with acute coronary syndrome between 2009 and 2014, with a one-year follow-up period. We defined cardiovascular and non-cardiovascular multimorbidity as having at least two prior comorbidities before the index hospitalization. Multivariable adjusted Cox proportional models were built to assess the one-year risk of recurrent cardiovascular events, defined as cardiovascular mortality and non-fatal myocardial infarction or stroke. The final model was adjusted for age, gender, body mass index, tobacco consumption, education, and family history of cardiovascular disease, prescription of high-dose statinsat discharge and use of cardiac rehabilitation after discharge.
Overall, 3,664 patients (65%) had no multimorbidity, 1,839 (33%) had cardiovascular multimorbidity, 62 (1%) had non-cardiovascular multimorbidity, and 70 (1%) had both cardiovascular and non-cardiovascular multimorbidity. The multivariate risk of recurrent cardiovascular events was increased among patients with cardiovascular multimorbidity (hazard ratio (HR) 2.05, 95% CI: 1.54-2.73, p<0.001) and patients with non-cardiovascular multimorbidity (HR 2.57, 95% CI: 1.04-6.35, p = 0.04) compared to patients without multimorbidity. Patients with cardiovascular and non-cardiovascular multimorbidity had the highest risk of recurrence with a HR of 5.19, 95% CI: 2.79-9.64, p<0.001, compared to patients without multimorbidity.
Multimorbidity increased by two-fold the risk of cardiovascular events over the year after an acute coronary syndrome. The magnitude of this increased risk was similar for patients with cardiovascular or non-cardiovascular multimorbidity.
Mots-clé
Acute Coronary Syndrome/complications, Acute Coronary Syndrome/diagnosis, Acute Coronary Syndrome/mortality, Aged, Aged, 80 and over, Cardiovascular Diseases/complications, Cardiovascular Diseases/mortality, Female, Hospitalization, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use, Male, Middle Aged, Multimorbidity, Multivariate Analysis, Prognosis, Proportional Hazards Models, Prospective Studies, Recurrence, Risk Factors, Treatment Outcome
Pubmed
Web of science
Open Access
Oui
Création de la notice
19/04/2018 19:29
Dernière modification de la notice
20/08/2019 15:08
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