Article: article d'un périodique ou d'un magazine.
Pregnancy after breast cancer: Are young patients willing to participate in clinical studies?
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Young patients with breast cancer (BC) are often concerned about treatment-induced infertility and express maternity desire. Conception after BC does not seem to affect outcome, but information in estrogen-receptor positive (ER+) disease is not definitive. From September 2012-March 2013, 212 evaluable patients with ER+ early BC, <37 years at diagnosis, from 5 regions (Europe/US/Canada/Middle-East/Australia) answered a survey about fertility concerns, maternity desire and interest in a study of endocrine therapy (ET) interruption to allow pregnancy. Overall, 37% of respondents were interested in the study; younger patients (≤30 years) reported higher interest (57%). Motivation in younger patients treated >30 months was higher (83%) than in older women (14%), interest was independent of age in patients treated for ≤30 months. A prospective study in this patient population seems relevant and feasible. The International-Breast-Cancer-Study-Group (IBCSG), within the Breast-International-Group (BIG) - North-American-Breast-Cancer-Groups (NABCG) collaboration, is launching a study (POSITIVE) addressing ET interruption to allow pregnancy.
Adult, Age Factors, Breast Neoplasms/chemistry, Breast Neoplasms/drug therapy, Clinical Trials as Topic/psychology, Feasibility Studies, Female, Fertility Preservation/methods, Fertility Preservation/psychology, Humans, Patient Participation/psychology, Pregnancy, Pregnancy Complications, Neoplastic/drug therapy, Pregnancy Complications, Neoplastic/pathology, Receptors, Estrogen, Surveys and Questionnaires, Withholding Treatment
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