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Effects of alpha-phosphoglucomutase deficiency on cell wall properties and fitness in Streptococcus gordonii.
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Streptococcus gordonii alpha-phosphoglucomutase, which converts glucose 6-phosphate to glucose 1-phosphate, is encoded by pgm. The pgm transcript is monocistronic and is initiated from a sigma(A)-like promoter. Mutants with a gene disruption in pgm exhibited an altered cell wall muropeptide pattern and a lower teichoic acid content, and had reduced fitness both in vitro and in vivo. In vitro, the reduced fitness included reduced growth, reduced viability in the stationary phase and increased autolytic activity. In vivo, the pgm-deficient strain had a lower virulence in a rat model of experimental endocarditis.
Base Sequence, Cell Wall/chemistry, Cell Wall/metabolism, Endocarditis, Bacterial/microbiology, Endocarditis, Bacterial/physiopathology, Gene Deletion, Gene Expression Regulation, Bacterial, Molecular Sequence Data, Phosphoglucomutase/chemistry, Phosphoglucomutase/genetics, Sequence Analysis, DNA, Streptococcal Infections/microbiology, Streptococcal Infections/physiopathology, Streptococcus/enzymology, Streptococcus/genetics, Virulence
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