Chlorpromazine-induced vanishing bile duct syndrome leading to biliary cirrhosis

Details

Serval ID
serval:BIB_5304D37D30B7
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Chlorpromazine-induced vanishing bile duct syndrome leading to biliary cirrhosis
Journal
Hepatology
Author(s)
Moradpour  D., Altorfer  J., Flury  R., Greminger  P., Meyenberger  C., Jost  R., Schmid  M.
ISSN
0270-9139 (Print)
Publication state
Published
Issued date
12/1994
Volume
20
Number
6
Pages
1437-41
Notes
Case Reports
Journal Article --- Old month value: Dec
Abstract
We describe a 33-yr-old pregnant woman in whom a primary biliary cirrhosis-like syndrome developed after 2 wk of chlorpromazine therapy. The clinical course was characterized by severe jaundice lasting 22 mo, intense pruritus, fever, steatorrhea, high alkaline phosphatase levels and hypercholesterolemia. Jaundice resolved with initiation of ursodeoxycholic acid therapy, but subclinical cholestasis and low-level inflammatory activity persisted and ultimately evolved into biliary cirrhosis. The pathological substrate of this severe and prolonged cholestatic reaction was found to be the vanishing bile duct syndrome with a marked transient pseudoxanthomatosis.
Keywords
Adult Bile Ducts/*drug effects/pathology Biopsy Chlorpromazine/*adverse effects Cholestasis/*chemically induced/complications/pathology Female Humans Liver/pathology Liver Cirrhosis, Biliary/*etiology/pathology Pregnancy *Pregnancy Complications Syndrome
Pubmed
Web of science
Create date
25/01/2008 16:06
Last modification date
20/08/2019 14:08
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