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Is high-grade adenomatous hyperplasia an early bronchioloalveolar adenocarcinoma?
Journal of Pathology
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Atypical adenomatous hyperplasia (AAH) is a probable forerunner of bronchioloalveolar carcinoma (BAC) and pulmonary adenocarcinoma (AC) of mixed type. The present study analysed four low-grade AAHs, 13 high-grade AAHs, two BACs, nine mixed ACs, and one squamous cell carcinoma derived from 13 patients using comparative genomic hybridization. The average number of chromosomal aberrations was 1.2 in low-grade AAH, 9.6 in high-grade AAH, and 12.5 in AC. A high degree of overlap of genetic changes was found in high-grade AAH, BAC, and AC within individual patients. The high number of aberrations and the degree of shared aberrations found in high-grade AAH and AC raises questions about the separation of these two entities. In addition, in view of the monoclonal origin of multiple foci within the same patient, AAH may not be a precursor of AC in some cases, but rather may represent intraepithelial spread.
Adenocarcinoma, Bronchiolo-Alveolar/genetics, Adenocarcinoma, Bronchiolo-Alveolar/pathology, Adenoma/genetics, Adenoma/pathology, Carcinoma, Squamous Cell/genetics, Carcinoma, Squamous Cell/pathology, Chromosomes, Human, X/genetics, DNA, Neoplasm/genetics, Humans, Hybridization, Genetic/genetics, Hyperplasia/pathology, Lung Neoplasms/genetics, Lung Neoplasms/pathology, Neoplasm Invasiveness/genetics, Polymerase Chain Reaction/methods, Precancerous Conditions/genetics, Precancerous Conditions/pathology, Sex Chromosome Aberrations
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