Blood plasma lipidomic signature of epicardial fat in healthy obese women.

Détails

ID Serval
serval:BIB_52C7C83AFFD6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Blood plasma lipidomic signature of epicardial fat in healthy obese women.
Périodique
Obesity
Auteur(s)
Scherer M., Montoliu I., Qanadli S.D., Collino S., Rezzi S., Kussmann M., Giusti V., Martin F.P.
ISSN
1930-739X (Electronic)
ISSN-L
1930-7381
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
23
Numéro
1
Pages
130-137
Langue
anglais
Notes
Publication types: Journal Article ; Observational Study
Résumé
OBJECTIVES: A lipidomic approach was employed in a clinically well-defined cohort of healthy obese women to explore blood lipidome phenotype ascribed to body fat deposition, with emphasis on epicardial adipose tissue (EAT).
METHODS: The present investigation delivered a lipidomics signature of epicardial adiposity under healthy clinical conditions using a cohort of 40 obese females (age: 25-45 years, BMI: 28-40 kg/m(2) ) not showing any metabolic disease traits. Lipidomics analysis of blood plasma was employed in combination with in vivo quantitation of mediastinal fat depots by computerized tomography.
RESULTS: All cardiac fat depots correlated to indicators of hepatic dysfunctions (ALAT and ASAT), which describe physiological connections between hepatic and cardiac steatosis. Plasma lipidomics encompassed overall levels of lipid classes, fatty acid profiles, and individual lipid species. EAT and visceral fat associated with diacylglycerols (DAG), triglycerides, and distinct phospholipid and sphingolipid species. A pattern of DAG and phosphoglycerols was specific to EAT.
CONCLUSIONS: Human blood plasma lipidomics appears to be a promising clinical and potentially diagnostic readout for patient stratification and monitoring. Association of blood lipidomics signature to regio-specific mediastinal and visceral adiposity under healthy clinical conditions may help provide more biological insights into obese patient stratification for cardiovascular disease risks.
Mots-clé
Adipose Tissue/metabolism, Adipose Tissue/radiography, Adiposity, Adult, Cohort Studies, Diglycerides/blood, Fatty Acids/blood, Female, Health, Humans, Lipids/blood, Metabolomics, Middle Aged, Obesity/blood, Obesity/metabolism, Pericardium/metabolism, Pericardium/radiography, Phospholipids/blood, Sphingolipids/blood, Tomography, X-Ray Computed, Triglycerides/blood, Young Adult
Pubmed
Web of science
Création de la notice
10/12/2014 12:39
Dernière modification de la notice
20/08/2019 15:08
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