Assessment of myocardial function and perfusion in a canine model of non-occlusive coronary artery stenosis using fast magnetic resonance imaging.

Détails

ID Serval
serval:BIB_528E060549BE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Assessment of myocardial function and perfusion in a canine model of non-occlusive coronary artery stenosis using fast magnetic resonance imaging.
Périodique
Journal of Magnetic Resonance Imaging
Auteur(s)
Schwitter J., Saeed M., Wendland M.F., Sakuma H., Bremerich J., Canet E., Higgins C.B.
ISSN
1053-1807 (Print)
ISSN-L
1053-1807
Statut éditorial
Publié
Date de publication
1999
Volume
9
Numéro
1
Pages
101-110
Langue
anglais
Résumé
Magnetic resonance (MR) functional and perfusion imaging were employed in a canine model of coronary artery stenosis (n = 6) for the quantification of functional and perfusion deficits before and after dipyridamole administration. Left anterior descending and circumflex (LCX) coronary blood flow were measured continuously after placing Doppler flowmeters. Inversion recovery gradient echo images during the transit of MR contrast medium gadolinium-benzyloxypropionictetraacetate dimeglumine (Gd-BOPTA/Dimeg) and fast breath-hold cine MR images were acquired at baseline, during LCX stenosis in basal state, and during LCX stenosis with vasodilation (dipyridamole 0.5 mg/kg). The extent of the functional defect and perfusion defect was expressed as percent of left ventricle (LV) circumference. During stenosis (LCX flow: 62.6 +/- 5.6% of baseline) the extent of the functional defect was slightly larger than the perfusion defect (11.0 +/- 1.8% versus 6.3 +/- 1.70% of LV circumference, respectively; P < 0.01). During vasodilation the extent of the functional defect was considerably smaller than the perfusion defect (25.3 +/- 2.5% versus 35.3 +/- 3.5%; P < 0.01). Thus, the sizes of ischemic regions displayed by MR perfusion defect and functional defect differ from each other.
Mots-clé
Animals, Contrast Media, Coronary Circulation/physiology, Coronary Disease/diagnosis, Dipyridamole/diagnostic use, Dogs, Gadolinium/diagnostic use, Magnetic Resonance Imaging/methods, Meglumine/analogs & derivatives, Meglumine/diagnostic use, Myocardial Contraction/physiology, Myocardial Ischemia/diagnosis, Myocardium/pathology, Organometallic Compounds/diagnostic use, Vasodilator Agents/diagnostic use, Ventricular Function, Left/physiology
Pubmed
Web of science
Création de la notice
07/09/2011 19:20
Dernière modification de la notice
20/08/2019 15:07
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