The neonatal Fc receptor is not required for mucosal infection by mouse mammary tumor virus.

Details

Serval ID
serval:BIB_5262BFD48C80
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The neonatal Fc receptor is not required for mucosal infection by mouse mammary tumor virus.
Journal
Journal of Virology
Author(s)
Velin D., Acha-Orbea H., Kraehenbuhl J.P.
ISSN
0022-538X (Print)
ISSN-L
0022-538X
Publication state
Published
Issued date
1996
Volume
70
Number
10
Pages
7250-7254
Language
english
Abstract
The milk-borne mouse mammary tumor virus (MMTV) infects newborn mice via the intestine. Infection is initially restricted to Peyer's patches and later spreads to the epithelial cells of the mammary gland. The receptor that mediates uptake and transport of MMTV across the intestinal barrier has not yet been identified, The neonatal Fc receptor (nFcR), which is expressed by enterocytes during the first two weeks of life, is downregulated at weaning, and its disappearance correlates with the onset of intestinal resistance to MMTV. To test whether the nFcR mediates transport and allows infection, we foster nursed on infected MMTV mothers beta2 microglobulin-deficient (beta2m-deficient) newborn mice that are unable to express the nFcR at the surface of their enterocytes. Exposure of beta2m-deficient mice to milk-borne virus resulted in the deletion of peripheral blood T cells reactive to the superantigen encoded by MMTV. Since beta2m-deficient newborn mice are susceptible to MMTV infection despite the lack of the nFcR, we conclude that the nFcR is not required for MMTV transport.
Keywords
Animals, Animals, Newborn, Intestinal Mucosa/immunology, Intestinal Mucosa/virology, Mammary Tumor Virus, Mouse, Mice, Receptors, Fc/immunology, Retroviridae Infections/immunology, T-Lymphocytes/immunology, Tumor Virus Infections/immunology
Pubmed
Web of science
Create date
24/01/2008 14:48
Last modification date
20/08/2019 14:07
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