A physiologically based pharmacokinetic model for arsenic exposure. I. Development in hamsters and rabbits

Détails

ID Serval
serval:BIB_5253
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
A physiologically based pharmacokinetic model for arsenic exposure. I. Development in hamsters and rabbits
Périodique
Toxicology and Applied Pharmacology
Auteur(s)
Mann S., Droz P.O., Vahter M.
ISSN
0041-008X
Statut éditorial
Publié
Date de publication
1996
Peer-reviewed
Oui
Volume
137
Numéro
1
Pages
8-22
Langue
anglais
Résumé
A physiologically based pharmacokinetic model for exposure to inorganic arsenic in hamsters and rabbits has been developed. The model in its present state simulates three routes of exposure to inorganic arsenic: oral intake, intravenous injection, and intratracheal instillation. It describes the tissue concentrations and the urinary and fecal excretions of the four arsenic metabolites: inorganic As(III) and As(V), methylarsonic acid, and dimethylarsinic acid. The model consists of five tissue compartments, chosen according to arsenic affinities: liver, kidneys, lungs, skin, and others. The model is based on physiological parameters, which were scaled according to body weight. When physiological parameters were not available, the data for the model were obtained by fitting (tissue affinity, absorption rate, and metabolic rate constants). The excretions of the arsenic metabolites in urine and feces are well simulated with the model for both species. Further validation of the arsenic metabolite concentrations in the tissues and in vitro measurements of the tissue affinity constants are discussed.
Mots-clé
Administration, Oral, Animals, Arsenic/administration & dosage, Arsenic/metabolism, Computer Simulation, Cricetinae, Digestive System/metabolism, Energy Metabolism, Injections, Intravenous, Intubation, Intratracheal, Lung/metabolism, Models, Biological, Rabbits, Tissue Distribution
Pubmed
Web of science
Création de la notice
19/11/2007 13:41
Dernière modification de la notice
03/03/2018 17:13
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