Phoxilium vs Hemosol-B0 for continuous renal replacement therapy in acute kidney injury.

Détails

ID Serval
serval:BIB_524C753DD358
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Phoxilium vs Hemosol-B0 for continuous renal replacement therapy in acute kidney injury.
Périodique
Journal of Critical Care
Auteur(s)
Chua H.R., Schneider A.G., Baldwin I., Collins A., Ho L., Bellomo R.
ISSN
1557-8615 (Electronic)
ISSN-L
0883-9441
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
28
Numéro
5
Pages
884.e7-884.14
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
PURPOSE: This study aimed to compare the biochemical effects of Phoxilium (containing phosphate at 1.2 mmol/L; Gambro Lundia AB, Lund, Sweden) and Hemosol-B0 (Gambro Lundia AB) as dialysate and/or replacement fluid during continuous renal replacement therapy (CRRT).
METHODS: We examined serum biochemistry in critically ill patients for 42 hours of Phoxilium administration for the prevention of hypophosphatemia during CRRT and compared them with corresponding results in random historical controls who received Hemosol-B0.
RESULTS: We studied 15 patients in each arm (Phoxilium vs Hemosol-B0). Respective median ages were 57 (49-68) and 64 (57-67) years. Baseline patient illness severity scores, prescribed CRRT effluent rates, and cumulative phosphate intakes were comparable. After 36 to 42 hours of Phoxilium administration, serum phosphate levels increased from 0.95 (0.81-1.13) to 1.44 (1.23-1.78) mmol/L, in contrast to the decline from 1.71 (1.09-2.00) to 0.83 (0.55-1.59) mmol/L with Hemosol-B0 (P=.0001). Serum ionized calcium levels decreased from 1.27 (1.22-1.37) to 1.12 (1.06-1.21) mmol/L with Phoxilium, compared with an increase from 1.09 (0.90-1.19) to 1.20 (1.16-1.25) mmol/L with Hemosol-B0 (P<.0001). Serum bicarbonate, base excess levels, and effective strong ion difference decreased with Phoxilium and were lower than those with Hemosol-B0 at 36 to 42 hours (P<.05).
CONCLUSION: Phoxilium effectively prevented hypophosphatemia during CRRT but was associated with relative metabolic acidosis and hypocalcemia compared with Hemosol-B0 use.
Mots-clé
Acute Kidney Injury/therapy, Aged, Blood Substitutes/therapeutic use, Case-Control Studies, Critical Illness, Dialysis Solutions/therapeutic use, Female, Humans, Hypophosphatemia/prevention & control, Male, Middle Aged, Phosphates/therapeutic use, Renal Replacement Therapy/methods, Retrospective Studies, Treatment Outcome
Pubmed
Web of science
Création de la notice
26/11/2014 22:36
Dernière modification de la notice
03/03/2018 17:13
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