The biochemistry of drug metabolism--an introduction: part 4. reactions of conjugation and their enzymes.

Détails

ID Serval
serval:BIB_523BB0F76E6E
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
The biochemistry of drug metabolism--an introduction: part 4. reactions of conjugation and their enzymes.
Périodique
Chemistry & Biodiversity
Auteur(s)
Testa B., Krämer S.D.
ISSN
1612-1880
Statut éditorial
Publié
Date de publication
2008
Volume
5
Numéro
11
Pages
2171-336
Langue
anglais
Résumé
This review continues a general presentation of the metabolism of drugs and other xenobiotics begun in three recent issues of Chemistry & Biodiversity. The present Part is dedicated to reactions of conjugation, namely methylation, sulfonation, and phosphorylation, glucuronidation and other glycosidations, acetylation and other acylations, the formation and fate of coenzyme A conjugates, glutathione conjugation, and the reaction of amines with carbonyl compounds. It presents the many transferases involved, their nomenclature, relevant biochemical properties, catalytic mechanisms, and the reactions they catalyze. Nonenzymatic reactions, mainly of glutathione conjugation, also receive due attention. A number of medicinally, environmentally, and toxicologically relevant examples are presented and discussed.
Mots-clé
Acetylation, Coenzyme A, Glucuronosyltransferase, Glutathione Transferase, Humans, Methylation, Pharmaceutical Preparations, Phosphorylation, Xenobiotics
Pubmed
Création de la notice
21/01/2009 16:13
Dernière modification de la notice
03/03/2018 17:13
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