The function and regulation of acid-sensing ion channels (ASICs) and the epithelial Na(+) channel (ENaC): IUPHAR Review 19.

Détails

Ressource 1Télécharger: BIB_52266DFA56FD.P001.pdf (1650.70 [Ko])
Etat: Serval
Version: Author's accepted manuscript
Document(s) secondaire(s)
Télécharger: Boscardin_ENaC-ASIC_review_post-print.pdf (5131.54 [Ko])
Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_52266DFA56FD
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
The function and regulation of acid-sensing ion channels (ASICs) and the epithelial Na(+) channel (ENaC): IUPHAR Review 19.
Périodique
British Journal of Pharmacology
Auteur(s)
Boscardin E., Alijevic O., Hummler E., Frateschi S., Kellenberger S.
ISSN
1476-5381 (Electronic)
ISSN-L
0007-1188
Statut éditorial
Publié
Date de publication
09/2016
Peer-reviewed
Oui
Volume
173
Numéro
18
Pages
2671-2701
Langue
anglais
Notes
Publication types: Journal Article ; ReviewPublication Status: ppublish
Résumé
Acid-sensing ion channels (ASICs) and the epithelial Na(+) channel (ENaC) are both members of the ENaC/degenerin family of amiloride-sensitive Na(+) channels. ASICs act as proton sensors in the nervous system where they contribute, besides other roles, to fear behaviour, learning and pain sensation. ENaC mediates Na(+) reabsorption across epithelia of the distal kidney and colon and of the airways. ENaC is a clinically used drug target in the context of hypertension and cystic fibrosis, while ASIC is an interesting potential target. Following a brief introduction, here we will review selected aspects of ASIC and ENaC function. We discuss the origin and nature of pH changes in the brain and the involvement of ASICs in synaptic signalling. We expose how in the peripheral nervous system, ASICs cover together with other ion channels a wide pH range as proton sensors. We introduce the mechanisms of aldosterone-dependent ENaC regulation and the evidence for an aldosterone-independent control of ENaC activity, such as regulation by dietary K(+) . We then provide an overview of the regulation of ENaC by proteases, a topic of increasing interest over the past few years. In spite of the profound differences in the physiological and pathological roles of ASICs and ENaC, these channels share many basic functional and structural properties. It is likely that further research will identify physiological contexts in which ASICs and ENaC have similar or overlapping roles.
Pubmed
Open Access
Oui
Création de la notice
18/06/2016 18:59
Dernière modification de la notice
08/05/2019 18:37
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