Specific inhibition of the JNK pathway promotes locomotor recovery and neuroprotection after mouse spinal cord injury.

Détails

ID Serval
serval:BIB_520C186F82FE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Specific inhibition of the JNK pathway promotes locomotor recovery and neuroprotection after mouse spinal cord injury.
Périodique
Neurobiology of Disease
Auteur(s)
Repici M., Chen X., Morel M.P., Doulazmi M., Sclip A., Cannaya V., Veglianese P., Kraftsik R., Mariani J., Borsello T., Dusart I.
ISSN
1095-953X (Electronic)
ISSN-L
0969-9961
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
46
Numéro
3
Pages
710-721
Langue
anglais
Résumé
Limiting the development of secondary damage represents one of the major goals of neuroprotective therapies after spinal cord injury. Here, we demonstrate that specific JNK inhibition via a single intraperitoneal injection of the cell permeable peptide D-JNKI1 6h after lesion improves locomotor recovery assessed by both the footprint and the BMS tests up to 4 months post-injury in mice. JNK inhibition prevents c-jun phosphorylation and caspase-3 cleavage, has neuroprotective effects and results in an increased sparing of white matter at the lesion site. Lastly, D-JNKI1 treated animals show a lower increase of erythrocyte extravasation and blood brain barrier permeability, thus indicating protection of the vascular system. In total, these results clearly point out JNK inhibition as a promising neuroprotective strategy for preventing the evolution of secondary damage after spinal cord injury.
Mots-clé
JNK, c-jun, Caspase-3, Spinal cord injury, Neuroprotection, Locomotor recovery
Pubmed
Web of science
Création de la notice
23/05/2012 11:50
Dernière modification de la notice
03/03/2018 17:12
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