Neurobiological mechanisms in the transition from drug use to drug dependence

Détails

ID Serval
serval:BIB_520165B841C4
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Neurobiological mechanisms in the transition from drug use to drug dependence
Périodique
Neuroscience and Biobehavioral Reviews
Auteur(s)
Koob George F., Ahmed Serge H., Boutrel Benjamin, Chen Scott A., Kenny Paul J., Markou Athina, O'Dell Laura E., Parsons Loren H., Sanna Pietro Paolo
ISSN
0149-7634
Statut éditorial
Publié
Date de publication
2004
Peer-reviewed
Oui
Volume
27
Numéro
8
Pages
739-749
Langue
anglais
Notes
SAPHIRID:67387
Résumé
Drug addiction is a chronic relapsing disorder characterized by compulsive drug intake, loss of control over intake, and impairment in social and occupational function. Animal models have been developed for various stages of the addiction cycle with a focus in our work on the motivational effects of drug dependence. A conceptual framework focused on allostatic changes in reward function that lead to excessive drug intake provides a heuristic framework with which to identify the neurobiologic mechanisms involved in the development of drug addiction. Neuropharmacologic studies in animal models have provided evidence for the dysregulation of specific neurochemical mechanisms in specific brain reward and stress circuits that provide the negative motivational state that drives addiction. The allostatic model integrates molecular, cellular and circuitry neuroadaptations in brain motivational systems produced by chronic drug ingestion with genetic vulnerability, and provides a new opportunity to translate advances in animal studies to the human condition.
Pubmed
Web of science
Création de la notice
11/03/2008 15:07
Dernière modification de la notice
03/03/2018 17:12
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