Basis of the gabamimetic profile of ethanol.

Détails

ID Serval
serval:BIB_51F3DDF285C0
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Basis of the gabamimetic profile of ethanol.
Périodique
Alcoholism, clinical and experimental research
Auteur(s)
Breese G.R., Criswell H.E., Carta M., Dodson P.D., Hanchar H.J., Khisti R.T., Mameli M., Ming Z., Morrow A.L., Olsen R.W., Otis T.S., Parsons L.H., Penland S.N., Roberto M., Siggins G.R., Valenzuela C.F., Wallner M.
ISSN
0145-6008 (Print)
ISSN-L
0145-6008
Statut éditorial
Publié
Date de publication
04/2006
Peer-reviewed
Oui
Volume
30
Numéro
4
Pages
731-744
Langue
anglais
Notes
Publication types: Congresses ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
This article summarizes the proceedings of a symposium held at the 2005 Research Society on Alcoholism meeting. The initial presentation by Dr. Wallner provided evidence that selected GABA(A) receptors containing the delta subunit display sensitivity to low intoxicating ethanol concentrations and this sensitivity is further increased by a mutation in the cerebellar alpha6 subunit, found in alcohol-hypersensitive rats. Dr. Mameli reported that ethanol affects gamma-aminobutyric acid (GABA) function by affecting neural circuits that influence GABA release. Dr. Parsons presented data from electrophysiological and microdialysis investigations that ethanol is capable of releasing GABA from presynaptic terminals. Dr. Morrow demonstrated that systemic ethanol increases neuroactive steroids in brain, the absence of which alters various functional responses to ethanol. Dr. Criswell presented evidence that the ability of ethanol to increase GABA was apparent in some, but not all, brain regions indicative of regional specificity. Further, Dr. Criswell demonstrated that neurosteroids alone and when synthesized locally by ethanol act postsynaptically to enhance the effect of GABA released by ethanol in a region specific manner. Collectively, this series of reports support the GABAmimetic profile of acutely administered ethanol being dependent on several specific mechanisms distinct from a direct effect on the major synaptic isoforms of GABA(A) receptors.

Mots-clé
Alcoholism/genetics, Amygdala/drug effects, Amygdala/secretion, Anesthetics/pharmacology, Animals, Cerebellum/chemistry, Ethanol/pharmacology, Interneurons/drug effects, Interneurons/physiology, Point Mutation, Progesterone/physiology, Rats, Receptors, GABA-A/drug effects, Receptors, GABA-A/genetics, Receptors, GABA-A/physiology, Steroids/physiology, gamma-Aminobutyric Acid/physiology, gamma-Aminobutyric Acid/secretion
Pubmed
Web of science
Création de la notice
24/03/2017 15:27
Dernière modification de la notice
03/03/2018 17:12
Données d'usage