La théorie de la mémoire métabolique: remet-elle en question notre stratégie thérapeutique face au diabète de type 2? [Will the theory of metabolic memory change our therapeutic strategies in the face of type 2 diabetes?]

Détails

ID Serval
serval:BIB_51D58E3E0D98
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
La théorie de la mémoire métabolique: remet-elle en question notre stratégie thérapeutique face au diabète de type 2? [Will the theory of metabolic memory change our therapeutic strategies in the face of type 2 diabetes?]
Périodique
Revue Médicale Suisse
Auteur(s)
Ruiz  J., Egli  M.
ISSN
1660-9379
Statut éditorial
Publié
Date de publication
06/2005
Volume
1
Numéro
22
Pages
1485-6, 1488-90
Notes
1660-9379 (Print) Journal Article Review --- Old month value: Jun 1 --- Old uritopublisher value: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16025887
Résumé
Many prospective studies have shown that tight glucose control reduces the risk of vascular complications in type 1 and type 2 diabetes. Besides, the intensive treatment group benefited from a preventive effect several years after the end of the study. In type 2 diabetes, the low glucose levels at the time of the diagnosis strongly correlate to the risk reduction of late complications. These various elements suggest the presence of a metabolic memory which would engage in very premature stages various pathways favoring the vascular development of diabetic complications. Our therapeutic strategy, based on thresholds of intervention favors the therapeutic slowness and strengthens negatively the metabolic memory. Therapeutic approach based on the tendencies to hyperglycemia could improve the prevention of the diabetic vascular complications.
Mots-clé
Blood Glucose/metabolism Diabetes Mellitus, Type 2/drug therapy/*metabolism Diabetic Angiopathies/metabolism/*prevention & control Energy Metabolism English Abstract Humans
Pubmed
Création de la notice
03/03/2008 16:15
Dernière modification de la notice
03/03/2018 17:12
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