The role of macrophage migration inhibitory factor in Alzheimer's disease.

Détails

ID Serval
serval:BIB_51D50F0FE5BE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The role of macrophage migration inhibitory factor in Alzheimer's disease.
Périodique
Molecular Medicine (cambridge, Mass.)
Auteur(s)
Bacher M., Deuster O., Aljabari B., Egensperger R., Neff F., Jessen F., Popp J., Noelker C., Reese J.P., Al-Abed Y., Dodel R.
ISSN
1528-3658 (Electronic)
ISSN-L
1076-1551
Statut éditorial
Publié
Date de publication
2010
Peer-reviewed
Oui
Volume
16
Numéro
3-4
Pages
116-121
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
Previous studies have shown that amyloid beta protein (Abeta ), the essential molecule for the formation of toxic oligomers and, subsequently, Alzheimer plaques, has been associated in vivo with the immune modulator, macrophage migration inhibitory factor (MIF) (17). To further investigate this association in vivo we used the APP transgenic mouse model. Serial brain sections of transgenic APP mice were stained for Abeta plaques and MIF and we observed MIF immunolabeling in microglial cells in association with Abeta plaques in the transgenic mouse brain sections. In addition, functional studies in murine and human neuronal cell lines revealed that Abeta-induced toxicity could be reversed significantly by a small molecule inhibitor of MIF (ISO-1). Finally, to elucidate the role of MIF in Alzheimer's Disease (AD) we measured MIF levels in the brain cytosol and cerebrospinal fluid (CSF) of AD patients and age-matched controls. Our results demonstrate a marked increase of MIF levels within the CSF of AD patients compared with controls. Combined, our results indicate a strong role for MIF in the pathogenesis of AD and furthermore suggest that inhibition of MIF may provide a valuable avenue of investigation for the prevention of disease onset, progression and/or severity.
Mots-clé
Aged, Alzheimer Disease/cerebrospinal fluid, Alzheimer Disease/metabolism, Amyloid beta-Peptides/metabolism, Amyloid beta-Protein Precursor/genetics, Analysis of Variance, Animals, Brain/metabolism, Brain Chemistry, Cell Survival/drug effects, Female, Histocytochemistry, Humans, Intramolecular Oxidoreductases/antagonists & inhibitors, Intramolecular Oxidoreductases/cerebrospinal fluid, Isoxazoles/pharmacology, Macrophage Migration-Inhibitory Factors/antagonists & inhibitors, Macrophage Migration-Inhibitory Factors/cerebrospinal fluid, Male, Mice, Mice, Transgenic, Neuroblastoma, Protease Nexins, Receptors, Cell Surface/genetics, Statistics, Nonparametric, Tumor Cells, Cultured
Pubmed
Open Access
Oui
Création de la notice
29/10/2012 12:09
Dernière modification de la notice
08/05/2019 18:36
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