T cell receptors in autoimmune disease as targets for immune intervention.

Détails

ID Serval
serval:BIB_51C624A7DFF9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
T cell receptors in autoimmune disease as targets for immune intervention.
Périodique
Genome / National Research Council Canada = Génome / Conseil National de Recherches Canada
Auteur(s)
Acha-Orbea H., Steinman L., McDevitt H.O.
ISSN
0831-2796 (Print)
ISSN-L
0831-2796
Statut éditorial
Publié
Date de publication
1989
Volume
31
Numéro
2
Pages
656-661
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Résumé
The optimal form of treatment for an autoimmune disease should be highly specific, have few side effects, and allow treatment of clinically apparent disease. One target that could fulfill these requirements is the T cell receptor. To answer the question whether treatment of autoimmune disease is possible with anti-T cell receptor antibodies, the heterogeneity of T cell receptor elements utilized in the T cell mediated autoimmune disease experimental allergic encephalomyelitis was analyzed. The limited heterogeneity of these elements allowed prevention and treatment of clinical autoimmune disease with anti-T cell receptor monoclonal antibodies. These results and their potential value for other autoimmune diseases are discussed.
Mots-clé
Animals, Antibodies, Monoclonal/immunology, Antibodies, Monoclonal/therapeutic use, Autoantigens/immunology, Autoimmune Diseases/immunology, Autoimmune Diseases/prevention & control, Encephalomyelitis, Autoimmune, Experimental/immunology, Encephalomyelitis, Autoimmune, Experimental/prevention & control, Mice, Mice, Inbred Strains, Myelin Basic Protein/immunology, Peptide Fragments/immunology, Receptors, Antigen, T-Cell/genetics, Receptors, Antigen, T-Cell/immunology
Pubmed
Web of science
Création de la notice
24/01/2008 15:48
Dernière modification de la notice
03/03/2018 17:11
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