Interplay between keratinocytes and immune cells--recent insights into psoriasis pathogenesis.

Détails

ID Serval
serval:BIB_51C2109254B0
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Interplay between keratinocytes and immune cells--recent insights into psoriasis pathogenesis.
Périodique
International Journal of Biochemistry and Cell Biology
Auteur(s)
Tonel G., Conrad C.
ISSN
1878-5875 (Electronic)
ISSN-L
1357-2725
Statut éditorial
Publié
Date de publication
2009
Volume
41
Numéro
5
Pages
963-968
Langue
anglais
Notes
Publication types: Journal Article ; Review
Résumé
Psoriasis is one of the most common human inflammatory skin diseases characterised by hyperproliferation and aberrant differentiation of keratinocytes. The trigger of the typical epidermal changes seen in psoriasis was considered to be a dysregulated immune response with Th-1/Tc1 cells playing a central role. Recent studies have provided new insights into psoriasis pathogenesis in defining intraepidermal alpha(1)beta(1)+ T cells as key effectors driving keratinocyte changes. Critical roles for IFN-alpha secreted by plasmacytoid dendritic cells and the IL-23/Th-17 axis were postulated. Initially, these subsequent stages are at least partially driven by the endogenous antimicrobial peptide LL37 that converts inert self-DNA into a potent trigger of interferon production by binding and delivering the DNA into plasmacytoid dendritic cells to trigger toll-like receptor 9. As LL37 is expressed by keratinocytes upon various stimuli, keratinocytes might regain momentum as instigators of an aberrant immune response which then precedes the characteristic changes in the epidermis. Data from these new studies indicate a complex interplay between keratinocytes overexpressing antimicrobial peptides and immune cells driving epidermal hyperproliferation and aberrant keratinocyte differentiation in the pathogenesis of psoriasis.
Mots-clé
Animals, Cell Communication/immunology, Dendritic Cells/immunology, Dendritic Cells/pathology, Humans, Keratinocytes/immunology, Keratinocytes/pathology, Psoriasis/immunology, Psoriasis/pathology, T-Lymphocytes/immunology, T-Lymphocytes/pathology
Pubmed
Web of science
Création de la notice
26/03/2012 11:29
Dernière modification de la notice
03/03/2018 17:11
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