Carcinome rénal métastatique, retour vers le futur... [Metastatic renal cell carcinoma, back to the future]

Détails

ID Serval
serval:BIB_51ABC794800F
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Carcinome rénal métastatique, retour vers le futur... [Metastatic renal cell carcinoma, back to the future]
Périodique
Revue medicale suisse
Auteur(s)
Martins F., Berthold D.
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Statut éditorial
Publié
Date de publication
18/05/2016
Peer-reviewed
Oui
Volume
12
Numéro
519
Pages
994-998
Langue
français
Notes
Publication types: English Abstract ; Journal Article
Publication Status: ppublish
Résumé
Renal cell carcinoma (RCC) is composed of several histopathological entities. There are more than 1,000 new cases in Switzerland every year, one third of which are diagnosed at an advanced stage. The development of chemotherapy had no impact on its overall prognosis. Since the mid-2000s, treatment of metastatic RCC was transformed by the arrival of targeted therapies. In the early 90s, high dose interleukine-2 (IL-2) allowed first cases of complete response, demonstrating the immunogenicity of RCC. More than twenty years after its first steps, immunotherapy progressed due to the recently approved nivolumab (an anti-PD1 monoclonal antibody) in second line of treatment. This review outlines the progress that has been made in the understanding and treatment of this pathology.

Mots-clé
Antibodies, Monoclonal/therapeutic use, Antineoplastic Agents/therapeutic use, Carcinoma, Renal Cell/diagnosis, Carcinoma, Renal Cell/drug therapy, Carcinoma, Renal Cell/pathology, Humans, Immunotherapy/methods, Kidney Neoplasms/diagnosis, Kidney Neoplasms/drug therapy, Kidney Neoplasms/pathology, Neoplasm Metastasis, Neoplasm Staging, Prognosis, Switzerland
Pubmed
Création de la notice
30/11/2016 22:11
Dernière modification de la notice
03/03/2018 17:11
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