Diversity of Cortico-descending Projections: Histological and Diffusion MRI Characterization in the Monkey.

Détails

ID Serval
serval:BIB_51A463519687
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Diversity of Cortico-descending Projections: Histological and Diffusion MRI Characterization in the Monkey.
Périodique
Cerebral cortex
Auteur(s)
Innocenti G.M., Caminiti R., Rouiller E.M., Knott G., Dyrby T.B., Descoteaux M., Thiran J.P.
ISSN
1460-2199 (Electronic)
ISSN-L
1047-3211
Statut éditorial
Publié
Date de publication
01/02/2019
Peer-reviewed
Oui
Volume
29
Numéro
2
Pages
788-801
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
The axonal composition of cortical projections originating in premotor, supplementary motor (SMA), primary motor (a4), somatosensory and parietal areas and descending towards the brain stem and spinal cord was characterized in the monkey with histological tract tracing, electron microscopy (EM) and diffusion MRI (dMRI). These 3 approaches provided complementary information. Histology provided accurate assessment of axonal diameters and size of synaptic boutons. dMRI revealed the topography of the projections (tractography), notably in the internal capsule. From measurements of axon diameters axonal conduction velocities were computed. Each area communicates with different diameter axons and this generates a hierarchy of conduction delays in this order: a4 (the shortest), SMA, premotor (F7), parietal, somatosensory, premotor F4 (the longest). We provide new interpretations for i) the well-known different anatomical and electrophysiological estimates of conduction velocity; ii) why conduction delays are probably an essential component of the cortical motor command; and iii) how histological and dMRI tractography can be integrated.
Pubmed
Web of science
Création de la notice
03/03/2018 13:48
Dernière modification de la notice
20/08/2019 15:07
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