Plasma 1-deoxysphingolipids are early predictors of incident type 2 diabetes mellitus.

Détails

Ressource 1Télécharger: journal.pone.0175776.pdf (721.94 [Ko])
Etat: Serval
Version: Final published version
ID Serval
serval:BIB_519D6B8C8E91
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Plasma 1-deoxysphingolipids are early predictors of incident type 2 diabetes mellitus.
Périodique
PloS one
Auteur(s)
Mwinyi J., Boström A., Fehrer I., Othman A., Waeber G., Marti-Soler H., Vollenweider P., Marques-Vidal P., Schiöth H.B., von Eckardstein A., Hornemann T.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Statut éditorial
Publié
Date de publication
2017
Peer-reviewed
Oui
Volume
12
Numéro
5
Pages
e0175776
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
1-Deoxysphingolipids (1-deoxySLs) are atypical sphingolipids, which are formed in a side reaction during sphingolipid de-novo synthesis. Recently, we demonstrated that 1-deoxySLs are biomarkers for the prediction of T2DM in obese, non-diabetic patients. Here we investigated the relevance of 1-deoxySLs as long-term predictive biomarkers for the incidence of T2DM in an asymptomatic population. Here, we analyzed the plasma sphingoid base profile in a nested group of non-diabetic individuals (N = 605) selected from a population-based study including 5 year follow-up data (CoLaus study). 1-DeoxySLs at baseline were significantly elevated in individuals who developed T2DM during the follow-up (p<0.001), together with increased glucose (p<5.11E-14), triglycerides (p<0.001) and HOMA-IR indices (p<0.001). 1-Deoxy-sphinganine (1-deoxySA) and 1-deoxy-sphingosine (1-deoxySO) were predictive for T2DM, even after adjusting for fasting glucose levels in the binary regression analyses. The predictive value of the combined markers 1-deoxySA+glucose were superior to glucose alone in normal-weight subjects (p<0.001) but decreased substantially with increasing BMI. Instead, plasma adiponectin and waist-to-hip ratio appeared to be better risk predictors for obese individuals (BMI>30kg/m2). In conclusion, elevated plasma 1-deoxySL levels are strong and independent risk predictors of future T2DM, especially for non-obese individuals in the general population.

Pubmed
Web of science
Open Access
Oui
Création de la notice
16/05/2017 18:10
Dernière modification de la notice
08/05/2019 18:35
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