Wisp1 is a circulating factor that stimulates proliferation of adult mouse and human beta cells.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_5193C3AD9295
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Wisp1 is a circulating factor that stimulates proliferation of adult mouse and human beta cells.
Journal
Nature communications
Author(s)
Fernandez-Ruiz R., García-Alamán A., Esteban Y., Mir-Coll J., Serra-Navarro B., Fontcuberta-PiSunyer M., Broca C., Armanet M., Wojtusciszyn A., Kram V., Young M.F., Vidal J., Gomis R., Gasa R.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Publication state
Published
Issued date
25/11/2020
Peer-reviewed
Oui
Volume
11
Number
1
Pages
5982
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Intramural
Publication Status: epublish
Abstract
Expanding the mass of pancreatic insulin-producing beta cells through re-activation of beta cell replication has been proposed as a therapy to prevent or delay the appearance of diabetes. Pancreatic beta cells exhibit an age-dependent decrease in their proliferative activity, partly related to changes in the systemic environment. Here we report the identification of CCN4/Wisp1 as a circulating factor more abundant in pre-weaning than in adult mice. We show that Wisp1 promotes endogenous and transplanted adult beta cell proliferation in vivo. We validate these findings using isolated mouse and human islets and find that the beta cell trophic effect of Wisp1 is dependent on Akt signaling. In summary, our study reveals the role of Wisp1 as an inducer of beta cell replication, supporting the idea that the use of young blood factors may be a useful strategy to expand adult beta cell mass.
Pubmed
Open Access
Yes
Create date
07/12/2020 15:30
Last modification date
12/01/2022 7:09
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