Ionotropic and metabotropic mechanisms in chemoreception: 'chance or design'?

Détails

ID Serval
serval:BIB_5185E0A6047E
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Ionotropic and metabotropic mechanisms in chemoreception: 'chance or design'?
Périodique
EMBO Reports
Auteur(s)
Silbering A.F., Benton R.
ISSN
1469-3178[electronic], 1469-221X[linking]
Statut éditorial
Publié
Date de publication
2010
Volume
11
Numéro
3
Pages
173-179
Langue
anglais
Résumé
Chemosensory receptors convert an enormous diversity of chemical signals from the external world into a common language of electrical activity in the brain. Mammals and insects use several families of transmembrane receptor proteins to recognize distinct classes of volatile and non-volatile chemicals that are produced by conspecifics or other environmental sources. A comparison of the signalling mechanisms of mammalian and insect receptors has revealed an unexpected functional distinction: mammals rely almost exclusively on metabotropic ligand-binding receptors, which use second messenger signalling cascades to indirectly activate ion channels, whereas insects use ionotropic receptors, which are gated directly by chemical stimuli, thereby leading to neuronal depolarization. In this review, we consider possible reasons for this dichotomy, taking into account biophysical, cell biological, ecological and evolutionary influences on how information is extracted from chemosensory cues by these animal classes.
Mots-clé
olfaction, gustation, receptor, GPCR, ion channel
Pubmed
Web of science
Création de la notice
01/03/2010 15:25
Dernière modification de la notice
20/08/2019 14:07
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