Involvement of the Tpl-2/cot oncogene in MMTV tumorigenesis.
Details
Serval ID
serval:BIB_5134
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Involvement of the Tpl-2/cot oncogene in MMTV tumorigenesis.
Journal
Oncogene
ISSN
0950-9232 (Print)
ISSN-L
0950-9232
Publication state
Published
Issued date
07/11/1996
Peer-reviewed
Oui
Volume
13
Number
9
Pages
2015-2020
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
We report for the first time a relationship between the Tpl-2/cot oncogene and Mouse Mammary Tumor Virus (MMTV) associated transformation of mammary gland cells. A sub-genomic library generated from a primary mammary gland tumor yielded a novel MMTV integration site which disrupted the Tpl-2/cot proto-oncogene between exons 7 and 8. Comparison of a cell line derived from normal mammary gland (comma-D) and a cell line established from an MMTV induced mammary tumor (GR) demonstrated similar rearrangements within Tpl-2/cot for the GR cells but not in the comma-D cells. These rearrangements in the cell line were accompanied by an increase in the level of Tpl-2/cot specific mRNA. This data suggests that Tpl-2/cot expression may be important in epithelial cell transformation or tumor progression.
Keywords
Animals, Base Sequence, Blotting, Southern, Cloning, Molecular, Epithelium/pathology, Female, Gene Expression Regulation, Neoplastic, Gene Rearrangement, MAP Kinase Kinase Kinases, Mammary Glands, Animal/pathology, Mammary Glands, Animal/virology, Mammary Neoplasms, Animal/genetics, Mammary Neoplasms, Animal/pathology, Mammary Neoplasms, Animal/virology, Mammary Tumor Virus, Mouse/genetics, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Inbred Strains, Mice, Transgenic, Molecular Sequence Data, Polymerase Chain Reaction/methods, Protein Serine-Threonine Kinases/biosynthesis, Protein Serine-Threonine Kinases/genetics, Proto-Oncogene Proteins/biosynthesis, Proto-Oncogene Proteins/genetics, RNA, Messenger/biosynthesis, Tumor Cells, Cultured
OAI-PMH
Pubmed
Web of science
Create date
19/11/2007 13:41
Last modification date
15/04/2023 6:51
Usage data
