Social meets molecular: Combining phylogenetic and latent class analyses to understand HIV-1 transmission in Switzerland.

Détails

ID Serval
serval:BIB_512FB5EBF7E1
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Social meets molecular: Combining phylogenetic and latent class analyses to understand HIV-1 transmission in Switzerland.
Périodique
American Journal of Epidemiology
Auteur(s)
Avila D., Keiser O., Egger M., Kouyos R., Böni J., Yerly S., Klimkait T., Vernazza P.L., Aubert V., Rauch A., Bonhoeffer S., Günthard H.F., Stadler T., Spycher B.D.
Collaborateur(s)
Swiss HIV Cohort Study
Contributeur(s)
Aubert V., Barth J., Battegay M., Bernasconi E., Böni J., Bucher HC., Burton-Jeangros C., Calmy A., Cavassini M., Egger M., Elzi L., Fehr J., Fellay J., Furrer H., Fux CA., Gorgievski M., Günthard H., Haerry D., Hasse B., Hirsch HH., Hösli I., Kahlert C., Kaiser L., Keiser O., Klimkait T., Kouyos R., Kovari H., Ledergerber B., Martinetti G., Martinez de Tejada B., Metzner K., Müller N., Nadal D., Pantaleo G., Rauch A., Regenass S., Rickenbach M., Rudin C., Schöni-Affolter F., Schmid P., Schultze D., Schüpbach J., Speck R., Staehelin C., Tarr P., Telenti A., Trkola A., Vernazza P., Weber R., Yerly S.
ISSN
1476-6256 (Electronic)
ISSN-L
0002-9262
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
179
Numéro
12
Pages
1514-1525
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
Switzerland has a complex human immunodeficiency virus (HIV) epidemic involving several populations. We examined transmission of HIV type 1 (HIV-1) in a national cohort study. Latent class analysis was used to identify socioeconomic and behavioral groups among 6,027 patients enrolled in the Swiss HIV Cohort Study between 2000 and 2011. Phylogenetic analysis of sequence data, available for 4,013 patients, was used to identify transmission clusters. Concordance between sociobehavioral groups and transmission clusters was assessed in correlation and multiple correspondence analyses. A total of 2,696 patients were infected with subtype B, 203 with subtype C, 196 with subtype A, and 733 with recombinant subtypes (mainly CRF02_AG and CRF01_AE). Latent class analysis identified 8 patient groups. Most transmission clusters of subtype B were shared between groups of gay men (groups 1-3) or between the heterosexual groups "heterosexual people of lower socioeconomic position" (group 4) and "injection drug users" (group 8). Clusters linking homosexual and heterosexual groups were associated with "older heterosexual and gay people on welfare" (group 5). "Migrant women in heterosexual partnerships" (group 6) and "heterosexual migrants on welfare" (group 7) shared non-B clusters with groups 4 and 5. Combining approaches from social and molecular epidemiology can provide insights into HIV-1 transmission and inform the design of prevention strategies.
Mots-clé
Adult, Female, HIV Infections/transmission, HIV Infections/virology, HIV-1/classification, HIV-1/genetics, Heterosexuality, Homosexuality, Humans, Male, Middle Aged, Phylogeny, Social Behavior, Sociology, Medical, Switzerland
Pubmed
Web of science
Création de la notice
05/08/2014 18:52
Dernière modification de la notice
03/03/2018 17:10
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