Analysis of blood from Zika virus-infected fetuses: a prospective case series.

Détails

ID Serval
serval:BIB_511B73F4F963
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Analysis of blood from Zika virus-infected fetuses: a prospective case series.
Périodique
The Lancet. Infectious diseases
Auteur(s)
Schaub B., Vouga M., Najioullah F., Gueneret M., Monthieux A., Harte C., Muller F., Jolivet E., Adenet C., Dreux S., Leparc-Goffart I., Cesaire R., Volumenie J.L., Baud D.
ISSN
1474-4457 (Electronic)
ISSN-L
1473-3099
Statut éditorial
Publié
Date de publication
05/2017
Peer-reviewed
Oui
Volume
17
Numéro
5
Pages
520-527
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Zika virus has spread through the Americas and the Caribbean since early 2015 and was rapidly declared a Public Health Emergency of International Concern by WHO because of the potential association with fetal anomalies. We analysed fetal and maternal fluids and tissues in fetuses with confirmed Zika virus infection prospectively monitored in Martinique, a French Caribbean island.
Since the beginning of the Zika virus outbreak in Martinique, all pregnant women undergo monthly fetal ultrasound examination surveillance. In this study, we prospectively studied all patients with fetal anomalies and a positive amniotic fluid for Zika virus by RT-PCR. Maternal and fetal blood, urine, amniotic fluid, placenta, and fetal tissues were tested for Zika virus by RT-PCR. Fetal blood was analysed to identify haematological and biological anomalies.
Between Jan 1, 2016, and Nov 10, 2016, we recruited eight cases of Zika virus infection. All but two cases were symptomatic during the first trimester. Fetal anomalies were only detected after 20 weeks' gestation. After an initial positive result, amniocentesis became negative in two cases and fetal blood was transiently Zika virus-positive in six cases. Fetal blood analyses showed a cholestatic pattern, anaemia, and infectious response.
Normalisation of amniotic fluid and fetal blood for Zika virus, as well as maternal blood and urine, shows the limitations of the performance of these investigations, due to the possibility of false negative results. Abnormal fetal blood needs to be investigated further to establish prognostic factors of severe Zika virus infections.
None.

Mots-clé
Adolescent, Adult, Biomarkers/blood, Biomarkers/urine, Female, Fetal Blood/virology, Fetus/abnormalities, Fetus/diagnostic imaging, Humans, Martinique, Microcephaly/diagnosis, Microcephaly/diagnostic imaging, Placenta, Pregnancy, Pregnancy Complications, Infectious/virology, Pregnancy Outcome, Pregnancy Trimester, First, Prospective Studies, RNA, Viral, Zika Virus/isolation & purification, Zika Virus Infection/blood, Zika Virus Infection/diagnosis, Zika Virus Infection/diagnostic imaging, Zika Virus Infection/transmission
Pubmed
Web of science
Création de la notice
28/02/2017 19:53
Dernière modification de la notice
20/08/2019 14:06
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