Article: article from journal or magazin.
Time of injection determines the effect of alpha-MSH antiserum on DA neurons in psychological stress
Male rats were subjected to "psychological stress" which consisted in 10 sec footshock on the first day followed 24 hr later by a 10 sec stay in the experimental chamber without shock. Intravenous antiserum against alpha-MSH markedly changed the functional state of mesencephalic and hypothalamic DA neurons (assessed by histochemical microfluorimetry) when administered before the second session but not when given before the first session. These observations reveal an interesting parallelism in the temporal characteristics of the effects of alpha-MSH on avoidance behavior and central DA systems.
Animals Brain/*physiopathology Dopamine/*physiology Humans Hypothalamus/physiopathology *Immune Sera Male Medulla Oblongata/physiopathology Melanocyte-Stimulating Hormones/*immunology Mesencephalon/physiopathology Microscopy, Fluorescence Neurons/*physiology Rats Stress, Psychological/*physiopathology Substantia Nigra/physiopathology
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