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Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases.
Caspases not only play an essential role during apoptotic cell death, but a subfamily of them-the inflammatory caspases-are associated with immune responses to microbial pathogens. Activation of inflammatory caspases, such as caspase-1 and caspase-5, occurs upon assembly of an intracellular complex, designated the inflammasome. This results in the cleavage and activation of the proinflammatory cytokines IL-1beta and IL-18. Mutations in one of the scaffold proteins of the inflammasome, NALP3/Cryopyrin, are associated with autoinflammatory disorders underscoring the importance of regulating inflammatory caspase activation.
Animals, Apoptosis/physiology, Autoimmunity/immunology, Autoimmunity/physiology, Caspases/antagonists & inhibitors, Caspases/immunology, Humans, Inflammation/enzymology, Inflammation/immunology, Interleukin-1/metabolism, Mice, Protein Structure, Tertiary
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