Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases.

Détails

ID Serval
serval:BIB_510A7DBBFECF
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases.
Périodique
Cell
Auteur(s)
Martinon F., Tschopp J.
ISSN
0092-8674 (Print)
ISSN-L
0092-8674
Statut éditorial
Publié
Date de publication
2004
Volume
117
Numéro
5
Pages
561-574
Langue
anglais
Résumé
Caspases not only play an essential role during apoptotic cell death, but a subfamily of them-the inflammatory caspases-are associated with immune responses to microbial pathogens. Activation of inflammatory caspases, such as caspase-1 and caspase-5, occurs upon assembly of an intracellular complex, designated the inflammasome. This results in the cleavage and activation of the proinflammatory cytokines IL-1beta and IL-18. Mutations in one of the scaffold proteins of the inflammasome, NALP3/Cryopyrin, are associated with autoinflammatory disorders underscoring the importance of regulating inflammatory caspase activation.
Mots-clé
Animals, Apoptosis/physiology, Autoimmunity/immunology, Autoimmunity/physiology, Caspases/antagonists & inhibitors, Caspases/immunology, Humans, Inflammation/enzymology, Inflammation/immunology, Interleukin-1/metabolism, Mice, Protein Structure, Tertiary
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 16:19
Dernière modification de la notice
08/05/2019 18:33
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