The role of the vascular endothelium in arenavirus haemorrhagic fevers.

Détails

ID Serval
serval:BIB_50FF1EBD243C
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
The role of the vascular endothelium in arenavirus haemorrhagic fevers.
Périodique
Thrombosis and Haemostasis
Auteur(s)
Kunz Stefan
ISSN
0340-6245
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
102
Numéro
6
Pages
1024-1029
Langue
anglais
Résumé
Viral haemorrhagic fevers (VHF) caused by arenaviruses are among the most devastating emerging human diseases. The most important pathogen among the arenaviruses is Lassa virus (LASV), the causative agent of Lassa fever that is endemic to West Africa. On the South American continent, the New World arenavirus Junin virus (JUNV), Machupo (MACV), Guanarito (GTOV), and Sabia virus (SABV) have emerged as causative agents of severe VHFs. Clinical and experimental studies on arenavirus VHF have revealed a crucial role of the endothelium in their pathogenesis. However, in contrast to other VHFs, haemorrhages are not a salient feature of Lassa fever and fatal cases do not show overt destruction of vascular tissue. The functional alteration of the vascular endothelium that precede shock and death in fatal Lassa fever may be due to more subtle direct or indirect effects of the virus on endothelial cells. Haemorrhagic disease manifestations and vascular involvement are more pronounced in the VHF caused by the South American haemorrhagic fever viruses. Recent studies on JUNV revealed perturbation of specific endothelial cell function, including expression of cell adhesion molecules, coagulation factors, and vasoactive mediators as a consequence of productive viral infection. These studies provided first possible links to some of the vascular abnormalities observed in patients, however, their relevance in vivo remains to be investigated.
Mots-clé
Endothelial Cells, Viral Infection, Virology, Fatal Lassa Fever, Junin-Virus, Mastomys-Natalensis, Complement-System, Dendritic Cells, Immune Plasma, Sierra-Leone, Infection, Phylogeny, World
Pubmed
Web of science
Création de la notice
12/01/2010 17:51
Dernière modification de la notice
03/03/2018 17:10
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