A genetic risk score is differentially associated with migraine with and without aura.

Détails

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Etat: Public
Version: de l'auteur
Licence: Non spécifiée
ID Serval
serval:BIB_50EA1F4D1679
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
A genetic risk score is differentially associated with migraine with and without aura.
Périodique
Human genetics
Auteur(s)
Pisanu C., Preisig M., Castelao E., Glaus J., Pistis G., Squassina A., Del Zompo M., Merikangas K.R., Waeber G., Vollenweider P., Mwinyi J. (co-dernier), Schiöth H.B. (co-dernier)
ISSN
1432-1203 (Electronic)
ISSN-L
0340-6717
Statut éditorial
Publié
Date de publication
08/2017
Peer-reviewed
Oui
Volume
136
Numéro
8
Pages
999-1008
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Although a number of migraine-associated single-nucleotide polymorphisms (SNP) with small effect size have been identified, little is known about the additive impact of these variants on migraine risk, frequency and severity. We investigated to what extent a genetic risk score (GRS) based on recently published, novel migraine-associated SNPs is associated with migraine prevalence, subtypes and severity in a large population-based sample. The sample comprised 446 subjects with migraine and 2511 controls from the CoLaus/PsyCoLaus study. Fifty-four SNPs earlier associated with migraine were selected. SNPs with a low impact on migraine prevalence in our sample were excluded using random forest. We combined the remaining 21 SNPs into a GRS and analyzed the association with migraine using logistic regression models. The GRS was significantly associated with migraine (OR = 1.56, p = 0.02) and migraine without aura (MWOA) (OR = 2.01, p = 0.003), but not with migraine with aura (MWA). The GRS was not associated with migraine frequency, intensity or interference with daily activities. We show that a GRS combining multiple genetic risk variants is associated with MWOA but not MWA, suggesting a different genetic susceptibility background underlying the two forms of migraine.

Mots-clé
Adult, Aged, Case-Control Studies, Cohort Studies, Female, Genetic Loci, Genotyping Techniques, Humans, Logistic Models, Male, Middle Aged, Migraine with Aura/genetics, Migraine without Aura/genetics, Polymorphism, Single Nucleotide, Prevalence, Risk Factors
Pubmed
Web of science
Open Access
Oui
Création de la notice
06/07/2017 10:10
Dernière modification de la notice
04/10/2019 13:34
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