Serum albumin is an early predictor of complications after liver surgery.

Détails

ID Serval
serval:BIB_50E74DED136A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Serum albumin is an early predictor of complications after liver surgery.
Périodique
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Auteur(s)
Labgaa I., Joliat G.R., Demartines N., Hübner M.
ISSN
1878-3562 (Electronic)
ISSN-L
1590-8658
Statut éditorial
Publié
Date de publication
05/2016
Peer-reviewed
Oui
Volume
48
Numéro
5
Pages
559-561
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
The morbidity associated with liver surgery remained substantially high despite considerable surgical and anesthetic improvements. The unmet need of accurate biomarkers to predict postoperative complications is widely accepted.
This pilot study aimed to assess serum albumin as a surrogate marker of surgical stress and to test its potential predictive role for postoperative complications.
This retrospective pilot study included 106 patients who underwent liver surgery between 2010 and 2014. Serum albumin levels were measured pre- and post-operatively. Maximal albumin decrease (AlbΔmin) was correlated with complications.
Serum albumin rapidly dropped after surgery. AlbΔmin was significantly increased in patients with complications (14.5±6.0g/L vs. 10.3±7.2, p=0.009). On multivariate analysis, ASA III/IV (p=0.016) and AlbΔmin (p=0.037) were the only predictors of overall complications.
Early postoperative drop of serum albumin reflects the intensity of the surgical stress and may predict complications after liver surgery. Serum albumin is a biomarker displaying precious features and deserving further prospective investigations.

Mots-clé
Aged, Biomarkers/blood, Female, Humans, Liver/surgery, Male, Middle Aged, Pilot Projects, Postoperative Complications/blood, Predictive Value of Tests, Retrospective Studies, Serum Albumin/metabolism, Stress, Physiological
Pubmed
Création de la notice
01/05/2016 17:28
Dernière modification de la notice
03/03/2018 17:09
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