Impact of inflammation on the relationship among alcohol consumption, mortality, and cardiac events: the health, aging, and body composition study

Détails

ID Serval
serval:BIB_50D5AF790A22
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Impact of inflammation on the relationship among alcohol consumption, mortality, and cardiac events: the health, aging, and body composition study
Périodique
Archives of Internal Medicine
Auteur(s)
Maraldi  C., Volpato  S., Kritchevsky  S. B., Cesari  M., Andresen  E., Leeuwenburgh  C., Harris  T. B., Newman  A. B., Kanaya  A., Johnson  K. C., Rodondi  N., Pahor  M.
ISSN
0003-9926 (Print)
Statut éditorial
Publié
Date de publication
07/2006
Peer-reviewed
Oui
Volume
166
Numéro
14
Pages
1490-7
Notes
Comparative Study Journal Article Multicenter Study Research Support, N.I.H., Extramural --- Old month value: Jul 24
Résumé
BACKGROUND: Uncertainty remains about the overall survival benefit of alcohol consumption and the mechanisms underlying the cardioprotective effect of light to moderate alcohol intake. Recent evidence suggests an anti-inflammatory effect of light to moderate alcohol consumption. We investigated the relationship of alcohol intake with all-cause mortality and cardiac events and evaluated whether this relationship is mediated or modified by inflammatory markers. METHODS: The analysis included 2487 subjects, aged 70 to 79 years, without baseline coronary heart disease (CHD) or heart failure (HF), participating in the Health, Aging, and Body Composition study. All-cause mortality and incident cardiac events (CHD and HF) were detected during a mean follow-up of 5.6 years. Alcohol consumption and serum levels of interleukin-6 (IL-6) and C-reactive protein (CRP) were assessed at baseline. RESULTS: A total of 397 participants died, and 383 experienced an incident cardiac event. Compared with never or occasional drinkers, subjects drinking 1 to 7 drinks per week had lower age-, sex-, and race-adjusted incidences of death (27.4 vs 20.1 per 1000 person-years, respectively) and cardiac events (28.9 vs 20.8 per 1000 person-years). After adjustment for confounders, compared with never or occasional drinkers, light to moderate drinkers (1-7 drinks per week) showed a decreased risk of death (hazard ratio [HR], 0.75; 95% confidence interval [CI], 0.56-1.00) and cardiac events (HR, 0.72; CI, 0.54-0.97). Adjustment for potential mediators, and particularly inflammatory marker levels, did not affect the strength of this association. CONCLUSION: Light to moderate alcohol consumption was associated with significantly lower rates of cardiac events and longer survival, independent of its anti-inflammatory effect.
Mots-clé
Aged Aging/*physiology Alcohol Drinking/blood/*epidemiology Biological Markers/blood Body Composition/*physiology C-Reactive Protein/*metabolism Female Follow-Up Studies Heart Diseases/blood/etiology/*mortality Humans Incidence Inflammation/*blood/complications Interleukin-6/*blood Male Prognosis Retrospective Studies Risk Factors Survival Rate/trends United States/epidemiology
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/01/2008 13:01
Dernière modification de la notice
08/05/2019 18:32
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