Anticorps antineuronaux: un domaine en plein développement [Anti-neuronal antibodies: a rapidly developing field].

Détails

ID Serval
serval:BIB_50B33579B2CE
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Anticorps antineuronaux: un domaine en plein développement [Anti-neuronal antibodies: a rapidly developing field].
Périodique
Revue Médicale Suisse
Auteur(s)
Zekeridou A., Rossetti A.O., Hottinger A.F., Du Pasquier R.A.
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Statut éditorial
Publié
Date de publication
2013
Volume
9
Numéro
384
Pages
909-914
Langue
français
Notes
Publication types: English Abstract ; Journal ArticlePublication Status: ppublish. PDF type: Le point sur...
Résumé
Anti-neuronal antibodies are implicated in various neurological syndromes that are sometimes associated with tumors. Depending on the antigenic target (nuclear, cytoplasmic or extracellular cell-surface or synaptic) the clinical presentation is different. In neurological syndromes associated with antibodies specific for intracellular antigens, the T-cell mediated immunological response predominates as pathogenic effector and the response to treatment is typically poor. In contrast, in syndromes related to antibodies against extracellular targets, the role of the antibodies is pathogenic and the neurological syndrome often responds better to immunomodulatory treatment, associated or not with an anti-tumoral treatment. We review the spectrum of anti-neuronal antibodies and their corresponding clinical and therapeutic characteristics.
Pubmed
Création de la notice
12/06/2013 16:24
Dernière modification de la notice
03/03/2018 17:09
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