Two cases of "cannabis acute psychosis" following the administration of oral cannabis.

Détails

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Etat: Serval
Version: Final published version
ID Serval
serval:BIB_50A330F58CDE
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Two cases of "cannabis acute psychosis" following the administration of oral cannabis.
Périodique
BMC psychiatry
Auteur(s)
Favrat B., Ménétrey A., Augsburger M., Rothuizen L.E., Appenzeller M., Buclin T., Pin M., Mangin P., Giroud C.
ISSN
1471-244X (Electronic)
ISSN-L
1471-244X
Statut éditorial
Publié
Date de publication
01/04/2005
Peer-reviewed
Oui
Volume
5
Pages
17
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Résumé
Cannabis is the most commonly used illegal drug and its therapeutic aspects have a growing interest. Short-term psychotic reactions have been described but not clearly with synthetic oral THC, especially in occasional users.
We report two cases of healthy subjects who were occasional but regular cannabis users without psychiatric history who developed transient psychotic symptoms (depersonalization, paranoid feelings and derealisation) following oral administration of cannabis. In contrast to most other case reports where circumstances and blood concentrations are unknown, the two cases reported here happened under experimental conditions with all subjects negative for cannabis, opiates, amphetamines, cocaine, benzodiazepines and alcohol, and therefore the ingested dose, the time-events of effects on behavior and performance as well as the cannabinoid blood levels were documented.
While the oral route of administration achieves only limited blood concentrations, significant psychotic reactions may occur.

Mots-clé
Acute Disease, Administration, Oral, Adult, Depersonalization/chemically induced, Dronabinol/administration & dosage, Dronabinol/blood, Dronabinol/pharmacology, Hallucinogens/administration & dosage, Hallucinogens/blood, Hallucinogens/pharmacology, Humans, Male, Marijuana Abuse/blood, Marijuana Abuse/etiology, Marijuana Smoking/epidemiology, Marijuana Smoking/psychology, Paranoid Disorders/chemically induced, Psychoses, Substance-Induced/blood, Psychoses, Substance-Induced/etiology
Pubmed
Web of science
Open Access
Oui
Création de la notice
08/02/2008 18:44
Dernière modification de la notice
08/05/2019 18:31
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