T cell fate specification and alphabeta/gammadelta lineage commitment.

Détails

ID Serval
serval:BIB_508F04692BC0
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
T cell fate specification and alphabeta/gammadelta lineage commitment.
Périodique
Current opinion in immunology
Auteur(s)
MacDonald H.R., Radtke F., Wilson A.
ISSN
0952-7915
Statut éditorial
Publié
Date de publication
2001
Peer-reviewed
Oui
Volume
13
Numéro
2
Pages
219-224
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
The development of T cells from pluripotent stem cells involves a coordinated series of lineage-commitment steps. Common lymphoid precursors in the fetal liver or adult bone marrow must first choose between a T, B or NK cell fate. Committed T cell precursors in the thymus then differentiate into cells committed to the alphabeta or gammadelta lineages. Recent advances have been made in our understanding of the mechanisms underlying T cell fate specification and alphabeta/gammadelta lineage divergence.
Mots-clé
Animals, Cell Differentiation, Cell Lineage, Dendritic Cells/cytology, Dendritic Cells/immunology, Digestive System/cytology, Digestive System/immunology, Humans, Killer Cells, Natural/cytology, Killer Cells, Natural/immunology, Receptors, Antigen, T-Cell, alpha-beta/metabolism, Receptors, Antigen, T-Cell, gamma-delta/metabolism, Stem Cells/cytology, Stem Cells/immunology, T-Lymphocytes/cytology, T-Lymphocytes/immunology
Pubmed
Web of science
Création de la notice
28/01/2008 12:39
Dernière modification de la notice
03/03/2018 17:09
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