Confounding factors and genetic polymorphism in the evaluation of individual steroid profiling

Détails

Ressource 1Télécharger: BIB_507DAA8A3E00.P001.pdf (1585.21 [Ko])
Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_507DAA8A3E00
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Confounding factors and genetic polymorphism in the evaluation of individual steroid profiling
Périodique
British Journal of Sports Medicine
Auteur(s)
Kuuranne T., Saugy M., Baume N.
ISSN
1473-0480 (Electronic)
ISSN-L
0306-3674
Statut éditorial
Publié
Date de publication
2014
Volume
48
Numéro
10
Pages
848-855
Langue
anglais
Notes
Publication types: Journal Article pdf: Review
Résumé
In the fight against doping, steroid profiling is a powerful tool to detect drug misuse with endogenous anabolic androgenic steroids. To establish sensitive and reliable models, the factors influencing profiling should be recognised. We performed an extensive literature review of the multiple factors that could influence the quantitative levels and ratios of endogenous steroids in urine matrix. For a comprehensive and scientific evaluation of the urinary steroid profile, it is necessary to define the target analytes as well as testosterone metabolism. The two main confounding factors, that is, endogenous and exogenous factors, are detailed to show the complex process of quantifying the steroid profile within WADA-accredited laboratories. Technical aspects are also discussed as they could have a significant impact on the steroid profile, and thus the steroid module of the athlete biological passport (ABP). The different factors impacting the major components of the steroid profile must be understood to ensure scientifically sound interpretation through the Bayesian model of the ABP. Not only should the statistical data be considered but also the experts in the field must be consulted for successful implementation of the steroidal module.
Mots-clé
Doping, Steroids
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/04/2014 13:14
Dernière modification de la notice
08/05/2019 18:31
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