Intrauterine devices and endometrial cancer risk : a pooled analysis of the Epidemiology of Endometrial Cancer Consortium

Détails

Ressource 1Télécharger: BIB_505ED2DA0520.P001.pdf (743.44 [Ko])
Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_505ED2DA0520
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Intrauterine devices and endometrial cancer risk : a pooled analysis of the Epidemiology of Endometrial Cancer Consortium
Périodique
International Journal of Cancer. Journal International Du Cancer
Auteur(s)
Felix A.S., Gaudet M.M., Vecchia C.L., Nagle C.M., Shu X.O., Weiderpass E., Adami H.O., Beresford S., Bernstein L., Chen C., Cook L.S., Vivo I.D., Doherty J.A., Friedenreich C.M., Gapstur S.M., Hill D., Horn-Ross P.L., Lacey J.V., Levi F., Liang X., Lu L., Magliocco A., McCann S.E., Negri E., Olson S.H., Palmer J.R., Patel A.V., Petruzella S., Prescott J., Risch H.A., Rosenberg L., Sherman M.E., Spurdle A.B., Webb P.M., Wise L.A., Xiang Y.B., Xu W., Yang H.P., Yu H., Zeleniuch-Jacquotte A., Brinton L.A.
ISSN
1097-0215 (Electronic)
ISSN-L
0020-7136
Statut éditorial
Publié
Date de publication
03/2015
Peer-reviewed
Oui
Volume
136
Numéro
5
Pages
E410-E422
Langue
anglais
Notes
IUMSP2015/03
Résumé
Intrauterine devices (IUDs), long-acting and reversible contraceptives, induce a number of immunological and biochemical changes in the uterine environment that could affect endometrial cancer (EC) risk. We addressed this relationship through a pooled analysis of data collected in the Epidemiology of Endometrial Cancer Consortium. We combined individual-level data from 4 cohort and 14 case-control studies, in total 8,801 EC cases and 15,357 controls. Using multivariable logistic regression, we estimated pooled odds ratios (pooled-ORs) and 95% confidence intervals (CIs) for EC risk associated with ever use, type of device, ages at first and last use, duration of use and time since last use, stratified by study and adjusted for confounders. Ever use of IUDs was inversely related to EC risk (pooled-OR = 0.81, 95% CI = 0.74-0.90). Compared with never use, reduced risk of EC was observed for inert IUDs (pooled-OR = 0.69, 95% CI = 0.58-0.82), older age at first use (≥35 years pooled-OR = 0.53, 95% CI = 0.43-0.67), older age at last use (≥45 years pooled-OR = 0.60, 95% CI = 0.50-0.72), longer duration of use (≥10 years pooled-OR = 0.61, 95% CI = 0.52-0.71) and recent use (within 1 year of study entry pooled-OR = 0.39, 95% CI = 0.30-0.49). Future studies are needed to assess the respective roles of detection biases and biologic effects related to foreign body responses in the endometrium, heavier bleeding (and increased clearance of carcinogenic cells) and localized hormonal changes.
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/11/2014 18:31
Dernière modification de la notice
08/05/2019 18:31
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