Facts and fallacies of blood pressure control in recent trials: implications in the management of patients with hypertension.

Details

Serval ID
serval:BIB_5055AD3E807D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Facts and fallacies of blood pressure control in recent trials: implications in the management of patients with hypertension.
Journal
Journal of Hypertension
Author(s)
Zanchetti A., Mancia G., Black H.R., Oparil S., Waeber B., Schmieder R.E., Bakris G.L., Messerli F.H., Kjeldsen S.E., Ruilope L.M.
ISSN
1473-5598 (Electronic)
ISSN-L
0263-6352
Publication state
Published
Issued date
2009
Volume
27
Number
4
Pages
673-679
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
A large body of clinical trial data indicates that a given difference in blood pressure (BP), as measured in the clinic, results in a given difference in outcome. This correlation underpins current US and European guidelines for the management of hypertension. However, findings from recent comparative trials may appear inconsistent with a fixed relationship between BP lowering and outcome benefit, at least at all BP ranges, at all levels of total cardiovascular risk and with all drug combinations. We review the findings of six of these recent trials and conclude that their complex design precludes a simple interpretation, that several important questions remain unanswered and that direct evidence - particularly in support of lowering systolic BP below 140 or 130 mmHg - is urgently needed.
Keywords
Aged, 80 and over, Antihypertensive Agents/therapeutic use, Blood Pressure, Blood Pressure Monitoring, Ambulatory, Clinical Trials as Topic, Diabetes Mellitus/physiopathology, Humans, Hypertension/drug therapy, Stroke/prevention & control, Vascular Diseases/physiopathology
Pubmed
Create date
15/12/2009 15:05
Last modification date
21/08/2019 5:33
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