Long-term calcineurin inhibition and magnesium balance after renal transplantation

Détails

ID Serval
serval:BIB_50445802768E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Long-term calcineurin inhibition and magnesium balance after renal transplantation
Périodique
Transplant International
Auteur(s)
Mazzola  B. L., Vannini  S. D., Truttmann  A. C., von Vigier  R. O., Wermuth  B., Ferrari  P., Bianchetti  M. G.
ISSN
0934-0874 (Print)
Statut éditorial
Publié
Date de publication
02/2003
Volume
16
Numéro
2
Pages
76-81
Notes
Journal Article --- Old month value: Feb
Résumé
Regulation of magnesium balance is achieved by a steady-state mechanism in which intake and output are maintained at an equal level. Dietary magnesium intake, total and ionized plasma magnesium levels, and urinary magnesium were assessed in 46 renal transplant recipients treated with cyclosporine, nine transplant recipients who had never been on cyclosporine, and 31 healthy volunteers. Dietary magnesium intake [13.5 (11.0-15.1) mmol/day vs 13.0 (11.1-16.0) mmol/day and 13.7 (11.4-16.7) mmol/day, respectively; median and interquartile range] and urinary magnesium excretion [4.31 (3.57-5.89) vs 4.39 (3.56-6.02) and 5.01 (3.73-6.01) mmol/day, respectively] were similar in renal transplant recipients treated with cyclosporine, transplant recipients who had never been on cyclosporine, and control subjects. Total [0.74 (0.70-0.78) vs 0.80 (0.74-0.84) and 0.81 (0.79-0.87) mmol/l), respectively] and ionized [0.49 (0.46-0.52) vs 0.53 (0.50-0.58) and 0.54 (0.52-0.59) mmol/l, respectively] plasma magnesium were significantly lower in renal transplant recipients on cyclosporine than in transplant recipients without cyclosporine, and healthy controls. These observations indicate a modified magnesium steady state in renal transplant recipients treated with cyclosporine.
Mots-clé
Adolescent Adult Aged Calcineurin/*antagonists & inhibitors Cyclosporine/*administration & dosage Enzyme Inhibitors/*administration & dosage Female Homeostasis Humans Kidney Diseases/*blood/surgery/urine *Kidney Transplantation Magnesium/*blood/urine Male Middle Aged Postoperative Complications/blood/urine
Pubmed
Web of science
Création de la notice
28/01/2008 14:50
Dernière modification de la notice
03/03/2018 17:08
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