Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization

Détails

ID Serval
serval:BIB_503BB7DECC2F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization
Périodique
Proceedings of the National Academy of Sciences of the United States of America
Auteur(s)
Pellerin  L., Magistretti  P. J.
ISSN
0027-8424 (Print)
Statut éditorial
Publié
Date de publication
10/1994
Volume
91
Numéro
22
Pages
10625-9
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Oct 25
Résumé
Glutamate, released at a majority of excitatory synapses in the central nervous system, depolarizes neurons by acting at specific receptors. Its action is terminated by removal from the synaptic cleft mostly via Na(+)-dependent uptake systems located on both neurons and astrocytes. Here we report that glutamate, in addition to its receptor-mediated actions on neuronal excitability, stimulates glycolysis--i.e., glucose utilization and lactate production--in astrocytes. This metabolic action is mediated by activation of a Na(+)-dependent uptake system and not by interaction with receptors. The mechanism involves the Na+/K(+)-ATPase, which is activated by an increase in the intracellular concentration of Na+ cotransported with glutamate by the electrogenic uptake system. Thus, when glutamate is released from active synapses and taken up by astrocytes, the newly identified signaling pathway described here would provide a simple and direct mechanism to tightly couple neuronal activity to glucose utilization. In addition, glutamate-stimulated glycolysis is consistent with data obtained from functional brain imaging studies indicating local nonoxidative glucose utilization during physiological activation.
Mots-clé
Aerobiosis Animals Animals, Newborn Astrocytes/drug effects/*metabolism Biological Transport Brain/metabolism/physiology/radionuclide imaging Cells, Cultured Cerebral Cortex/*metabolism Deoxyglucose/*metabolism Excitatory Amino Acid Antagonists/pharmacology Glutamic Acid/*metabolism/pharmacology *Glycolysis/drug effects Lactates/metabolism Mice Models, Neurological Na(+)-K(+)-Exchanging ATPase/metabolism Neurons/*metabolism/physiology Tritium
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 14:16
Dernière modification de la notice
08/05/2019 18:30
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