Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Mecanismes pathogeniques des maladies neurodegeneratives: l'exemple de la sclerose laterale amyotrophique. [Pathogenic mechanisms of neurodegenerative diseases: amyotrophic lateral sclerosis]
Revue Médicale Suisse
English Abstract Journal Article Review --- Old month value: May 3
Since its description by Charcot in 1869, the mechanism underlying the characteristic selective degeneration and death of motor neurons in amyotrophic lateral sclerosis (ALS) has remained a mystery. There is no effective remedy for this progressive, fatal disorder. Modern genetics have now identified two genes, SODI and ALS2 as primary causes of the disease and has implicated others as potential contributors. These insights have enabled development of model systems to test hypotheses of disease mechanism and potential therapies. Along with errors in the handling of synaptic glutamate and the potential excitotoxic response that it provokes, these model systems underscore the involvement of non-neuronal cells in disease progression and provide new therapeutic strategies.
Amyotrophic Lateral Sclerosis/*etiology Humans
Last modification date