Regional Delta Waves In Human Rapid Eye Movement Sleep.

Détails

Ressource 1Demande d'une copie Sous embargo jusqu'au 03/10/2019.
Etat: Public
Version: de l'auteur
Licence: Non spécifiée
ID Serval
serval:BIB_500BD059B81C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Regional Delta Waves In Human Rapid Eye Movement Sleep.
Périodique
The Journal of neuroscience
Auteur(s)
Bernardi G., Betta M., Ricciardi E., Pietrini P., Tononi G., Siclari F.
ISSN
1529-2401 (Electronic)
ISSN-L
0270-6474
Statut éditorial
Publié
Date de publication
03/04/2019
Peer-reviewed
Oui
Volume
39
Numéro
14
Pages
2686-2697
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Although the EEG slow wave of sleep is typically considered to be a hallmark of nonrapid eye movement (NREM) sleep, recent work in mice has shown that slow waves can also occur in REM sleep. Here, we investigated the presence and cortical distribution of negative delta (1-4 Hz) waves in human REM sleep by analyzing high-density EEG sleep recordings obtained in 28 healthy subjects. We identified two clusters of delta waves with distinctive properties: (1) a frontal-central cluster characterized by ∼2.5-3.0 Hz, relatively large, notched delta waves (so-called "sawtooth waves") that tended to occur in bursts, were associated with increased gamma activity and rapid eye movements (EMs), and upon source modeling displayed an occipital-temporal and a frontal-central component and (2) a medial-occipital cluster characterized by more isolated, slower (<2 Hz), and smaller waves that were not associated with rapid EMs, displayed a negative correlation with gamma activity, and were also found in NREM sleep. Therefore, delta waves are an integral part of REM sleep in humans and the two identified subtypes (sawtooth and medial-occipital slow waves) may reflect distinct generation mechanisms and functional roles. Sawtooth waves, which are exclusive to REM sleep, share many characteristics with ponto-geniculo-occipital waves described in animals and may represent the human equivalent or a closely related event, whereas medial-occipital slow waves appear similar to NREM sleep slow waves.SIGNIFICANCE STATEMENT The EEG slow wave is typically considered a hallmark of nonrapid eye movement (NREM) sleep, but recent work in mice has shown that it can also occur in REM sleep. By analyzing high-density EEG recordings collected in healthy adult individuals, we show that REM sleep is characterized by prominent delta waves also in humans. In particular, we identified two distinctive clusters of delta waves with different properties: a frontal-central cluster characterized by faster, activating "sawtooth waves" that share many characteristics with ponto-geniculo-occipital waves described in animals and a medial-occipital cluster containing slow waves that are more similar to NREM sleep slow waves. These findings indicate that REM sleep is a spatially and temporally heterogeneous state and may contribute to explaining its known functional and phenomenological properties.
Mots-clé
PGO wave, REM sleep, hd-EEG, sawtooth wave, slow wave
Pubmed
Web of science
Création de la notice
25/03/2019 11:23
Dernière modification de la notice
20/08/2019 15:06
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