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Hypoglycémie et traitement du diabète de type 2. Le retour à une normoglycémie n'est pas nécessairement la meilleure stratégie thérapeutique [Hypoglycemia and diabetes treatment: the return to normal glucose level is not always the best therapeutic strategy].
Revue Médicale Suisse
Publication types: English Abstract ; Journal ArticlePublication Status: ppublish. pdf type: perspective
Recent clinical trials with type 2 diabetic patients and the quest of normal glyceamic values, have revealed difficulties and limitations. These too normal glyceamic targets corresponding to the physiological standards are associated with very high rate of hypoglycemia and an increase of mortality. A too simplistic view of treatment: "the lowest, the better is in the diabetes" is no longer defensible. The knowledge from complex systems behavior invites us to search targets adapted to a new state of equilibrium due to loss of self-regulation. These targets should not aim the physiological standards but to be adapted to patient's situation. Shared decision-making and consensus are the two pillars of this new strategy supported by the new ADA-EASD guidelines.
Blood Glucose/analysis, Blood Glucose/physiology, Diabetes Mellitus, Type 2/blood, Diabetes Mellitus, Type 2/drug therapy, Humans, Hypoglycemia/blood, Hypoglycemia/physiopathology, Reference Standards, Standard of Care
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